Micro-flow photosynthesis of new dienophiles for inverse-electron-demand Diels–Alder reactions. Potential applications for pretargeted in vivo PET imaging† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc02933g Click here for additional data file.

Enzymatic modification of 5′-capped RNA with a 4-vinylbenzyl group provides a platform for photoclick and inverse electron-demand Diels–Alder reaction† †Electronic supplementary information (ESI) available: See DOI: 10.1039/c4sc03182b Click here for additional data file.

Chromium photocatalysis: accessing structural complements to Diels–Alder adducts with electron-deficient dienophiles† †Electronic supplementary information (ESI) available: Experimental procedures, characterization data, electrochemistry data, UV/visible data, NMR spectra. See DOI: 10.1039/c6sc03303b Click here for additional data file.

Nanoparticle “switch-on” by tetrazine triggering† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6cc05118a Click here for additional data file. Click here for additional data file. Click here for additional data file.

This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels-Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent d...

Aromatic “Redox Tag”-assisted Diels–Alder reactions by electrocatalysis† †Electronic supplementary information (ESI) available: Additional figures, tables and general, experimental, theoretical and spectral information. See DOI: 10.1039/c6sc02117d Click here for additional data file.

Electrocatalysis was employed to promote Diels–Alder reactions between electronically mismatched substrates. A catalytic amount of electricity was enough to complete the overall reactions and GC-MS monitoring and CV measurements clearly illustrated the electrocatalytic nature of the reactions, which involve an EC-backward-E mechanism. The electrocatalytic Diels–Alder reactions were rationally d...

Stereodivergent, Diels–Alder-initiated organocascades employing α,β-unsaturated acylammonium salts: scope, mechanism, and application† †Electronic supplementary information (ESI) available: Experimental procedures and characterization details for all new compounds including 1H and 13C NMR spectra, computational data, crystallographic data, chiral phase-HPLC traces. CCDC 972246. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc04273b Click here for additional data file. Click here for additional data file.

Chiral a,b-unsaturated acylammonium salts are novel dienophiles enabling enantioselective Diels–Alderlactonization (DAL) organocascades leading to cisand trans-fused, bicyclic gand d-lactones from readily prepared dienes, commodity acid chlorides, and a chiral isothiourea organocatalyst under mild conditions. We describe extensions of stereodivergent DAL organocascades to other racemic dienes b...